144 0001422996 XXXXXXXX LIVE 0001724521 Arcus Biosciences, Inc. 001-38419 3928 Point Eden Way Hayward CA 94545 1-510-694-6200 Juan Jaen Officer Class A Common Stock Goldman Sachs & Co. LLC 200 West Street New York NY 10282 50000 999500 120801086 11/17/2025 NYSE Class A Common Stock 05/29/2015 Acquired from issuer in private transaction The Issuer N 22396 05/29/2015 None Class A Common Stock 05/08/2015 Acquired from issuer in private transaction The Issuer N 27604 05/08/2015 None N The Juan Carlos Jaen and Anita Galeana 2000 Trust 3928 Point Eden Way Hayward CA 94545 Class A Common Stock 10/28/2025 19019 372011.64 The Juan Carlos Jaen and Anita Galeana 2000 Trust 3928 Point Eden Way Hayward CA 94545 Class A Common Stock 10/29/2025 673 14102.71 The Juan Carlos Jaen and Anita Galeana 2000 Trust 3928 Point Eden Way Hayward CA 94545 Class A Common Stock 10/29/2025 77167 1617034.48 The Juan Carlos Jaen and Anita Galeana 2000 Trust 3928 Point Eden Way Hayward CA 94545 Class A Common Stock 10/30/2025 4314 87638.91 The sales of shares set forth herein are made in connection with a selling plan dated 08/08/2025, that is intended to comply with Rule 10b5-1(c). All shares to be sold by the Juan Carlos Jaen and Anita Galeana 2000 Trust. 11/17/2025 08/08/2025 Goldman Sachs & Co. LLC on behalf of Jaun Jaen