X0306 4 2020-11-16 0 0001484565 SOLENO THERAPEUTICS INC SLNO 0001422484 Mackaness James H 203 REDWOOD SHORES PKWY, STE 500 REDWOOD CITY CA 94065 0 1 0 0 Chief Financial Officer Employee stock option (right to buy) 2.05 2020-11-16 4 A 0 300000 0.00 A 2030-11-16 Common Stock 300000 316060 D Twenty-five percent (25%) of the shares subject to the Option shall vest on the one year anniversary of November 11, 2020 (the "Vesting Commencement Date"), and one forty-eighth (1/48) of the total number of shares subject to the Option shall vest each month thereafter on the same day of the month as the Vesting Commencement Date (which is November 11, 2020), such that all of the shares subject to the Option will have vested as of the fourth anniversary of the Vesting Commencement Date, subject to Participant continuing to be a Service Provider through each such date. Following the initial twelve month term, if Mr. Mackaness is terminated without cause or his employment is voluntarily terminated for good reason within the period three month prior to through six months following a change of control then he will receive: 100% acceleration of shares subject to the option. /s/ James Mackaness 2020-11-18