Share-Based Compensation - Schedule of Stock Option Activity (Detail) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended	12 Months Ended
	Mar. 31, 2024	Dec. 31, 2023
Stock Option Shares
Shares, Outstanding at beginning balance (in shares)	4,579,659
Shares, Granted (in shares)	1,088,059
Shares, Exercised (in shares)	0
Shares, Expired/cancelled (in shares)	(294,831)
Shares, Outstanding at ending balance (in shares)	5,372,887	4,579,659
Shares, Options exercisable (in shares)	2,285,885
Shares, Vested and expected (in shares)	5,372,887
Weighted Average Exercise Price
Weighted Average Exercise Price, Outstanding at beginning balance (in dollars per share)	$ 14.11
Weighted Average Exercise Price, Granted (in dollars per share)	1.92
Weighted Average Exercise Price, Exercised (in dollars per share)	0
Weighted Average Exercise Price, Expired/cancelled (in dollars per share)	12.52
Weighted Average Exercise Price, Outstanding at ending balance (in dollars per share)	11.68	$ 14.11
Weighted Average Exercise Price, Options exercisable (in dollars per share)	13.92
Weighted Average Exercise Price, Vested and expected to vest (in dollars per share)	$ 11.68
Weighted Average Remaining Contractual Term, Outstanding	8 years 6 months 21 days	8 years 4 months 13 days
Weighted Average Remaining Contractual Term, Options exercisable	8 years 7 days
Weighted Average Remaining Contractual Term, Vested and expected to vest	8 years 6 months 21 days
Aggregate Intrinsic Value, Outstanding	$ 504	$ 25
Aggregate Intrinsic Value, Options exercisable	244
Aggregate Intrinsic Value, Vested and expected to vest	$ 504