Share-Based Compensation - Schedule of Stock Option Activity (Detail) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Shares
Shares, Outstanding at beginning balance (in shares)	2,990,423
Shares, Granted (in shares)	2,282,409
Shares, Exercised (in shares)	(41,633)
Shares, Expired/cancelled (in shares)	(651,540)
Shares, Outstanding at ending balance (in shares)	4,579,659	2,990,423
Shares, Options exercisable (in shares)	1,494,789
Weighted Average Exercise Price
Weighted Average Exercise Price, Outstanding at beginning balance (in dollars per share)	$ 19.28
Weighted Average Exercise Price, Granted (in dollars per share)	8.78
Weighted Average Exercise Price, Exercised (in dollars per share)	1.88
Weighted Average Exercise Price, Expired/cancelled (in dollars per share)	19.98
Weighted Average Exercise Price, Outstanding at ending balance (in dollars per share)	14.11	$ 19.28
Weighted Average Exercise Price, Options exercisable (in dollars per share)	$ 17.84
Weighted Average Remaining Contractual Term, Outstanding	8 years 4 months 13 days	8 years 7 months 2 days
Weighted Average Remaining Contractual Term, Options exercisable	7 years 2 months 19 days
Aggregate intrinsic value	$ 25	$ 2,849
Aggregate Intrinsic Value, Options exercisable	$ 25
Shares, Vested and expected to vest in shares)	4,579,659
Weighted Average Exercise Price, Vested and expected to vest (in dollars per share)	$ 14.11
Weighted Average Remaining Contractual Term, Vested and expected to vest	8 years 4 months 13 days
Aggregate Intrinsic Value, Vested and expected to vest	$ 25