Condensed Consolidated Statement of Stockholders' Equity (Unaudited) - USD ($)	Total	Common Stock [Member]	Additional Paid-In Capital [Member]	Accumulated Deficit [Member]
Balance at Dec. 31, 2017	$ 17,435,489	$ 2,707	$ 125,995,438	$ (108,562,656)
Balance, Shares at Dec. 31, 2017		27,070,038
Issuance of restricted stock		$ 6	(6)
Issuance of restricted stock, Shares		60,000
Issuance of common stock upon exercise of stock options	21,992	$ 2	21,990
Issuance of common stock upon exercise of stock options, Shares		16,802
Forfeiture of restricted stock, Shares		(741)
Stock-based compensation expense	1,079,721		1,079,721
Net and comprehensive loss	(7,425,532)			(7,425,532)
Balance at Mar. 31, 2018	11,111,670	$ 2,715	127,097,143	(115,988,188)
Balance, Shares at Mar. 31, 2018		27,146,099
Balance at Dec. 31, 2018	58,666,575	$ 4,059	177,621,807	(118,959,291)
Balance, Shares at Dec. 31, 2018		40,588,004
Cumulative effect of change in accounting principle			5,717	(5,717)
Stock-based compensation expense	621,685		621,685
Net and comprehensive loss	(8,492,825)			(8,492,825)
Balance at Mar. 31, 2019	$ 50,795,435	$ 4,059	$ 178,249,209	$ (127,457,833)
Balance, Shares at Mar. 31, 2019		40,588,004