SCHEDULE 13G 0001055951 XXXXXXXX LIVE Common Stock, par value $0.0001 per share 03/31/2025 0001422142 Whitehawk Therapeutics, Inc. 00032Q104 2 HEADQUARTERS PLAZA EAST BUILDING, 11TH FLOOR Morristown NJ 07960 Rule 13d-1(c) OrbiMed Advisors LLC DE 0.00 4166000.00 0.00 4166000.00 4166000.00 N 8.9 IA OrbiMed Genesis GP LLC DE 0.00 4166000.00 0.00 4166000.00 4166000.00 N 8.9 OO Whitehawk Therapeutics, Inc. 2 Headquarters Plaza, East Building, 11th Floor Morristown, New Jersey 07960 OrbiMed Advisors LLC OrbiMed Genesis GP LLC 601 Lexington Avenue, 54th Floor New York, NY 10022 Please refer to Item 4 on each cover sheet for each filing person. N IA OrbiMed Advisors LLC: 4,166,000 OrbiMed Genesis GP LLC: 4,166,000 OrbiMed Advisors LLC: 8.9% OrbiMed Genesis GP LLC: 8.9% OrbiMed Advisors LLC: 0 OrbiMed Genesis GP LLC: 0 OrbiMed Advisors LLC: 4,166,000 OrbiMed Genesis GP LLC: 4,166,000 OrbiMed Advisors LLC: 0 OrbiMed Genesis GP LLC: 0 OrbiMed Advisors LLC: 4,166,000 OrbiMed Genesis GP LLC: 4,166,000 Y N The Reporting Persons hold 8.9% of the shares of Common Stock in the aggregate on behalf of other persons who have the right to receive or the power to direct the receipt of dividends from, or proceeds from the sale of, such securities. OrbiMed Advisors LLC exercises investment and voting power over the shares of Common Stock through a management committee comprised of Carl L. Gordon, Sven H. Borho, and W. Carter Neild, each of whom disclaims beneficial ownership of the shares of Common Stock reported herein. Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. OrbiMed Advisors LLC /s/ Carl L. Gordon 05/15/2025 OrbiMed Genesis GP LLC /s/ Carl L. Gordon 05/15/2025