X0306 4 2019-01-08 0 0001422142 Aerpio Pharmaceuticals, Inc. ARPO 0001315797 Satter Muneer A C/O AERPIO PHARMACEUTICALS, INC. 9987 CARVER ROAD, SUITE 420 CINCINNATI OH 45242 1 0 1 0 Common Stock 2019-01-08 4 P 0 20000 2.1986 A 5578017 I See footnote Common Stock 2019-01-09 4 P 0 20000 2.3938 A 5598017 I See footnote Common Stock 2019-01-10 4 P 0 23818 2.4537 A 5621835 I See footnote All shares were purchased by Satter Medical Technology Partners, L.P. The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.065 to $2.44. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff at the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range. The amount in Column 5 includes (a) 976,568 shares that are held by the Muneer A. Satter Revocable Trust for which the Reporting Person serves as trustee and, in such capacity, has sole voting and dispositive power over all such shares, (b) 1,145,267 shares that are held by various other trusts and other entities for which the Reporting Person serves as trustee, investment advisor or manager and, in such capacity, has sole voting and dispositive power over all such shares, and (c) the remaining balance of shares are held by Satter Medical Technology Partners, L.P. for which the Reporting Person has sole voting and dispositive power over all such shares. The Reporting Person disclaims beneficial ownership of all shares included in clauses (b) and (c) of this footnote (3), except to the extent of his pecuniary interest. The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.34 to $2.55. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff at the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range. The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.36 to $2.52. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff at the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range. /s/ Robert M. Hayward, by Power of Attorney 2019-01-10