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Fair value re-measurement of share subscription agreement (Details)
€ / shares in Units, $ in Millions
1 Months Ended 11 Months Ended 12 Months Ended
Jan. 19, 2016
EUR (€)
Dec. 16, 2015
USD ($)
Dec. 16, 2015
EUR (€)
item
€ / shares
Jan. 19, 2016
EUR (€)
Dec. 31, 2015
EUR (€)
Dec. 31, 2016
EUR (€)
Dec. 31, 2017
EUR (€)
Dec. 31, 2016
EUR (€)
Dec. 31, 2015
EUR (€)
Jan. 31, 2016
item
Disclosure of fair value measurement of assets [line items]                    
Share subscription increase             € 363,924,000 € 326,271,000 € 278,703,000  
Deferred income         € 39,806,000 € 285,612,000 219,892,000 285,612,000 39,806,000  
Fair value at inception       € 419,052,000     1,057,309,000 419,052,000    
Movement of period (recognized in the income statement)               57,479,000 (30,632,000)  
Fair value at the end         419,052,000 1,057,309,000 € 1,257,329,000 1,057,309,000 419,052,000  
Number of counterparties | item     2              
Number of valuation date | item                   2
Gilead Sciences, Inc                    
Disclosure of fair value measurement of assets [line items]                    
Payment composed of license fee and equity investment | $   $ 725                
Share subscription increase € 392,120,658 $ 425                
Price per share including issuance premium | € / shares     € 58.00              
Derivative financial asset instrument strike price (Euro per share) | € / shares     € 58.00              
Fair value of derivative financial asset in case of recalculation         8,367,000       8,367,000  
Gilead Sciences, Inc | At fair value                    
Disclosure of fair value measurement of assets [line items]                    
Fair value at inception     € 39,003,000 8,371,000 39,003,000 65,850,000   € 8,371,000    
Movement of period (recognized in the income statement)       57,479,000 (30,632,000)          
Derecognition of the financial asset through the share premium account           € (65,850,000)        
Fair value at the end 65,850,000     65,850,000 € 8,371,000       € 8,371,000  
Gilead Sciences, Inc | Recurring fair value measurement                    
Disclosure of fair value measurement of assets [line items]                    
Net fair value gain 26,800,000                  
Derivatives [member] | Gilead Sciences, Inc | Recurring fair value measurement                    
Disclosure of fair value measurement of assets [line items]                    
Offsetting short-term financial asset (derivative) € 65,900,000     € 65,900,000