X0202 SCHEDULE 13G 0001801265 XXXXXXXX LIVE Ordinary shares, no nominal value per share (the "Ordinary Shares") 06/15/2026 0001421876 Lakefront Biotherapeutics NV 36315X101 SCHALIENHOEVEDREEF 20T 2800 MECHELEN C9 BELGIUM Rule 13d-1(c) Madison Avenue International LP E9 0 3606203 0 3606203 3606203 5.5 PN Madison Avenue Partners, LP DE 0 3606203 0 3606203 3606203 5.5 PN EMAI Management, LLC DE 0 3606203 0 3606203 3606203 5.5 OO Madison Avenue GP, LLC DE 0 3606203 0 3606203 3606203 5.5 OO Caraway Jackson Investments LLC DE 0 3606203 0 3606203 3606203 5.5 OO Eli Samaha X1 0 3606203 0 3606203 3606203 5.5 IN Lakefront Biotherapeutics NV Schalienhoevedreef 20T, 2800 Mechelen, Belgium, The names of the persons filing this statement on Schedule 13G (collectively, the "Reporting Persons") are: * Madison Avenue International LP, * Madison Avenue Partners, LP, * EMAI Management, LLC, * Madison Avenue GP, LLC, * Caraway Jackson Investments LLC, and * Eli Samaha. The principal business address for each of the Reporting Persons is 150 East 58th St, 14th Fl, New York, NY 10155. Madison Avenue International LP is a Cayman Islands exempted limited partnership. Madison Avenue Partners, LP is a Delaware limited partnership. Each of EMAI Management, LLC, Madison Avenue GP, LLC and Caraway Jackson Investments LLC is a Delaware limited liability company. Mr. Samaha is a citizen of the United States of America. N IA As of June 23, 2026, Madison Avenue International LP beneficially owned 3,606,203 shares of Ordinary Shares. Madison Avenue Partners, LP and Madison Avenue GP, LLC, as the investment manager and general partner of Madison Avenue International LP, respectively, may be deemed to be the beneficial owner of the Ordinary Shares owned directly by Madison Avenue International LP. EMAI Management, LLC, as the general partner of Madison Avenue Partners, LP, may be deemed to be the beneficial owner of the Ordinary Shares owned directly by Madison Avenue International LP. Caraway Jackson Investments LLC, as the owner of Madison Avenue GP, LLC, may be deemed to be the beneficial owner of the Ordinary Shares owned directly by Madison Avenue International LP. Mr. Samaha, as the non-member manager of Madison Avenue GP, LLC, the managing member of EMAI Management, LLC, and the majority owner of Caraway Jackson Investments LLC, may be deemed to be the beneficial owner of the Ordinary Shares owned by Madison Avenue International LP. The following percentage is based on 65,897,071 Ordinary Shares outstanding as of December 31, 2025, as disclosed in the Issuer's Annual Report on Form 20-F, filed with the Securities and Exchange Commission on March 26, 2026. As of June 23, 2026, the Reporting Persons may be deemed to have beneficially owned approximately 5.5% of the outstanding Ordinary Shares. See Cover Pages Items 5-9. See Cover Pages Items 5-9. See Cover Pages Items 5-9. See Cover Pages Items 5-9. Y Y Y N See Exhibit A Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. Exhibit A - Joint Filing Agreement Madison Avenue International LP /s/ Eli Samaha 06/23/2026 Madison Avenue Partners, LP /s/ Eli Samaha 06/23/2026 EMAI Management, LLC /s/ Eli Samaha 06/23/2026 Madison Avenue GP, LLC /s/ Eli Samaha 06/23/2026 Caraway Jackson Investments LLC /s/ Eli Samaha 06/23/2026 Eli Samaha /s/ Eli Samaha 06/23/2026 *The Reporting Persons disclaim beneficial ownership in the Ordinary Shares reported herein except to the extent of their pecuniary interest therein. The original statement shall be signed by each person on whose behalf the statement is filed or his authorized representative. If the statement is signed on behalf of a person by his authorized representative other than an executive officer or general partner of the filing person, evidence of the representative's authority to sign on behalf of such person shall be filed with the statement, provided, however, that a power of attorney for this purpose which is already on file with the Commission may be incorporated by reference. The name and any title of each person who signs the statement shall be typed or printed beneath his signature. Note. Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See s.240.13d-7 for other parties for whom copies are to be sent. Attention. Intentional misstatements or omissions of fact constitute Federal criminal violations (see 18 U.S.C. 1001).