X0306 4 2018-06-29 0 0001217234 CareDx, Inc. CDNA 0001421333 Nelles Mitchell J C/O CAREDX, INC. 3260 BAYSHORE BOULEVARD BRISBANE CA 94005 0 1 0 0 Chief Operating Officer Common Stock 2018-06-29 4 A 0 10000 0.00 A 89639 D Common Stock 2018-06-29 4 A 0 5000 0.00 A 94639 D Common Stock 2018-07-02 4 M 0 3649 3.70 A 98288 D Common Stock 2018-07-02 4 M 0 19250 5.27 A 117538 D Common Stock 2018-07-02 4 M 0 9000 2.30 A 126538 D Common Stock 2018-07-02 4 S 0 39649 12.4823 D 86889 D Employee Stock Option (right to buy) 12.24 2018-06-29 4 A 0 10000 0.00 A 2028-06-29 Common Stock 10000 10000 D Employee Stock Option (right to buy) 3.70 2018-07-02 4 M 0 3649 0.00 D 2020-04-08 Common Stock 3649 0 D Employee Stock Option (right to buy) 5.27 2018-07-02 4 M 0 19250 0.00 D 2026-01-22 Common Stock 19250 13750 D Employee Stock Option (right to buy) 2.30 2018-07-02 4 M 0 9000 0.00 D 2027-02-17 Common Stock 9000 3938 D The reported securities are represented by restricted stock units, 1/4th of which shall vest on June 1, 2019 and 1/4th of which shall vest on each anniversary thereafter. The reported securities are represented by restricted stock units, 100% of which were vested upon grant. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $12.25 to $12.68, inclusive. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer full information regarding the number of shares purchased or sold at each separate price. 1/4th of the shares subject to the option shall vest on June 1, 2019 and 1/48th of the shares subject to the option shall vest monthly thereafter. 1/4th of the shares subject to the option vested on January 1, 2011 and 1/48th of the shares subject to the option vested monthly thereafter. The shares were fully vested as of January 1, 2014. 1/4th of the shares subject to the option vested on January 22, 2017 and 1/48th of the shares subject to the option vest monthly thereafter. 1/4th of the shares subject to the option vested on January 27, 2018 and 1/48th of the shares subject to the option vest monthly thereafter. /s/ Peter Maag, as attorney-in-fact for Mitchell Nelles 2018-07-03