Segment Reporting - Schedule of Segment Loss, Including Significant Segment Expenses (Detail) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2025	Mar. 31, 2024
Segment Reporting Information [Line Items]
Revenue	$ 0	$ 0
Research and development expenses	3,054	3,463
General and administrative expenses	2,555	3,742
Other income, net	(108)	(92)
Net loss	(5,501)	(7,113)
Employee Related Expenses [Member]
Segment Reporting Information [Line Items]
Research and development expenses	622	606
General and administrative expenses	947	1,200
Professional Fees for Services [Member]
Segment Reporting Information [Line Items]
Research and development expenses	17	(20)
General and administrative expenses	1,138	2,000
Facilities and Other Expenses [Member]
Segment Reporting Information [Line Items]
Research and development expenses	16	2
General and administrative expenses	470	542
LTI-01 Program-Related Expenses [Member]
Segment Reporting Information [Line Items]
Research and development expenses	602	1,463
LTI-01 Program-Related Expenses [Member] | CMC Activities [Member]
Segment Reporting Information [Line Items]
Research and development expenses	537	1,420
LTI-01 Program-Related Expenses [Member] | Clinical Operation Activities [Member]
Segment Reporting Information [Line Items]
Research and development expenses	65	43
LTI-03 Program-Related Expenses [Member]
Segment Reporting Information [Line Items]
Research and development expenses	1,789	1,373
LTI-03 Program-Related Expenses [Member] | Preclinical Study Costs [Member]
Segment Reporting Information [Line Items]
Research and development expenses	556	82
LTI-03 Program-Related Expenses [Member] | CMC Activities [Member]
Segment Reporting Information [Line Items]
Research and development expenses	560	260
LTI-03 Program-Related Expenses [Member] | Clinical Operation Activities [Member]
Segment Reporting Information [Line Items]
Research and development expenses	673	1,031
Other Program-Related Expenses [Member]
Segment Reporting Information [Line Items]
Research and development expenses	$ 8	$ 39