Income Taxes - Schedule of Net Deferred Tax Liabilities (Detail) - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Deferred tax assets:
Net operating loss carryforwards	$ 12,387	$ 64,959
Research and development and orphan drug tax credit carryforwards	7,825	6,606
Capitalized research and development expenses	9,797	4,380
Accrued expenses and reserves	251	61
Depreciation and amortization	0
Lease liability	10	9
Stock compensation	1,514	1,442
Total deferred tax assets	31,784	77,457
Valuation allowance	(18,506)	(77,441)	$ (69,680)
Net deferred tax assets	13,278	16
Deferred tax liabilities:
Depreciation and amortization	(16,594)	(5)
Right of use asset	(10)	(11)
Total deferred tax liabilities	(16,604)	$ (16)
Net deferred tax asset (liability)	$ (3,326)