Nature of the Business and Basis of Presentation - Additional Information (Detail) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Dec. 31, 2021
Class of Stock [Line Items]
Proceeds from collaboration agreement	$ 34,910
Cash, cash equivalents and investments	32,382
Accumulated deficit	(261,870)	$ (245,456)
Common Stock [Member]
Class of Stock [Line Items]
Proceeds from sales of stock	145,467
Preferred Stock [Member]
Class of Stock [Line Items]
Proceeds from sales of stock	$ 131,211