X0206 3 2017-06-28 0 0001420565 AILERON THERAPEUTICS INC ALRN 0001709601 Annis Allen C/O AILERON THERAPEUTICS, INC. 281 ALBANY STREET CAMBRIDGE MA 02139 0 0 1 0 Stock Option (right to buy) 0.80 2018-02-18 Common Stock 7547 D Stock Option (right to buy) 1.30 2019-06-25 Common Stock 12076 D Stock Option (right to buy) 5.07 2024-03-13 Common Stock 55751 D Stock Option (right to buy) 5.07 2025-03-10 Common Stock 8050 D Stock Option (right to buy) 5.77 2027-03-02 Common Stock 24152 D These options are fully vested. These options were granted on March 13, 2014 and vested as to 12.5% of the shares on January 1, 2014 and vest thereafter as to 2.0833% of the shares in equal monthly installments until July 1, 2017. These options were granted on March 10, 2015 and vested as to 25% of the shares on January 1, 2016 and vest thereafter as to 2.0833% of the shares in equal monthly installments through January 1, 2020. These options were granted on March 2, 2017 and vest as to 2.0833% of the shares in equal monthly installments until March 2, 2021. Exhibit Index: 24.1 Power of Attorney /s/ Kira A. Nelson, Kira A. Nelson, as attorney-in-fact for Allen Annis 2017-06-28