<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<headerData>
<submissionType>144</submissionType>
<filerInfo>
<filer>
<filerCredentials>
<cik>0001420106</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>
</filerInfo>
</headerData>
<formData>
<issuerInfo>
<issuerCik>0001699350</issuerCik>
<issuerName>Shoulder Innovations, Inc.</issuerName>
<secFileNumber>001-42771</secFileNumber>
<issuerAddress>
<street1 xmlns="http://www.sec.gov/edgar/common">1535 Steele Avenue SW, Suite B</street1>
<city xmlns="http://www.sec.gov/edgar/common">Grand Rapids</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">MI</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">49507</zipCode>
</issuerAddress>
<issuerContactPhone>(616)-294-1026</issuerContactPhone>
<nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Gilde Healthcare Holding B.V.; Cooperatieve Gilde Healthcare V U.A.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
<relationshipsToIssuer>
<relationshipToIssuer>10% Stockholder</relationshipToIssuer>
</relationshipsToIssuer>
</issuerInfo>
<securitiesInformation>
<securitiesClassTitle>Common</securitiesClassTitle>
<brokerOrMarketmakerDetails>
<name>Van Lanschot Kempen N.V.</name>
<address>
<street1 xmlns="http://www.sec.gov/edgar/common">Beethovenstraat 300</street1>
<city xmlns="http://www.sec.gov/edgar/common">Amsterdam</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">P7</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">1077 WZ</zipCode>
</address>
</brokerOrMarketmakerDetails>
<noOfUnitsSold>200000</noOfUnitsSold>
<aggregateMarketValue>4850000.00</aggregateMarketValue>
<noOfUnitsOutstanding>20738226</noOfUnitsOutstanding>
<approxSaleDate>07/29/2026</approxSaleDate>
<securitiesExchangeName>NYSE</securitiesExchangeName>
</securitiesInformation>
<securitiesToBeSold>
<securitiesClassTitle>Common</securitiesClassTitle>
<acquiredDate>02/10/2023</acquiredDate>
<natureOfAcquisitionTransaction>Private placement of Series D convertible preferred stock; converted into common stock upon IPO closing 08/01/2025. Holding period tacks under Rule 144(d)(3)(ii).</natureOfAcquisitionTransaction>
<nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
<isGiftTransaction>N</isGiftTransaction>
<amountOfSecuritiesAcquired>1743156</amountOfSecuritiesAcquired>
<paymentDate>02/10/2023</paymentDate>
<natureOfPayment>Cash</natureOfPayment>
</securitiesToBeSold>
<securitiesToBeSold>
<securitiesClassTitle>Common</securitiesClassTitle>
<acquiredDate>03/06/2025</acquiredDate>
<natureOfAcquisitionTransaction>Private placement of Series E convertible preferred stock; converted into common stock upon IPO closing 08/01/2025. Holding period tacks under Rule 144(d)(3)(ii).</natureOfAcquisitionTransaction>
<nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
<isGiftTransaction>N</isGiftTransaction>
<amountOfSecuritiesAcquired>537326</amountOfSecuritiesAcquired>
<paymentDate>03/06/2025</paymentDate>
<natureOfPayment>Cash</natureOfPayment>
</securitiesToBeSold>
<securitiesToBeSold>
<securitiesClassTitle>Common</securitiesClassTitle>
<acquiredDate>08/01/2025</acquiredDate>
<natureOfAcquisitionTransaction>Purchase in the issuer's registered initial public offering at $15.00 per share. Not restricted securities; sold as control securities.</natureOfAcquisitionTransaction>
<nameOfPersonfromWhomAcquired>Underwriters</nameOfPersonfromWhomAcquired>
<isGiftTransaction>N</isGiftTransaction>
<amountOfSecuritiesAcquired>100000</amountOfSecuritiesAcquired>
<paymentDate>08/01/2025</paymentDate>
<natureOfPayment>Cash</natureOfPayment>
</securitiesToBeSold>
<nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
<remarks>The securities are held directly by Cooperatieve Gilde Healthcare V U.A. ("Gilde"). Gilde Healthcare V Management B.V. is the managing director of Gilde and has sole voting and dispositive power with respect to the shares held by Gilde. Gilde Healthcare V Management B.V. is owned by Gilde Healthcare Holding B.V. The managing partners of Gilde Healthcare Holding B.V. are Manapouri B.V. (of which Edwin de Graaf is the owner and managing director) and Martemanshurk B.V. (of which Pieter van der Meer is the owner and managing director).</remarks>
<noticeSignature>
<noticeDate>07/29/2026</noticeDate>
<signature>Edwin de Graaf</signature>
</noticeSignature>
</formData>
</edgarSubmission>
