Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Revenue
Product revenue, net	$ 2,194
Operating expenses:
Cost of sales	2,698
Research and development	11,551	$ 10,756
Selling, general and administrative	26,899	13,026
Total operating expenses	41,148	23,782
Loss from operations	(38,954)	(23,782)
Other income (expense):
Interest income	1,161	557
Interest expense	(3,919)	(632)
Other income (expense)	143	(22)
Total other income (expense)	(2,615)	(97)
Net loss	$ (41,569)	$ (23,879)
Net loss per common share, basic and diluted	$ (1.10)	$ (0.75)
Weighted average common shares outstanding, basic and diluted	37,620	31,704
Other comprehensive (loss) income:
Unrealized (losses) gains from available-for-sale securities, net of tax of $0	$ (169)	$ 9
Total other comprehensive (loss) income	(169)	9
Comprehensive loss	$ (41,738)	$ (23,870)