X0306 4 2016-05-16 0 0001419600 Flexion Therapeutics Inc FLXN 0001597407 Clayman Michael D. C/O FLEXION THERAPEUTICS, INC. 10 MALL ROAD, SUITE 301 BURLINGTON MA 01803 1 1 0 0 President and CEO Common Stock 2016-05-16 4 P 0 2000 9.5125 A 5568 D Common Stock 278661 I By the Michael D.Clayman 2006 Revocable Trust Common Stock 24600 I By the Michael D. Clayman Irrevocable Trust Common Stock 388683 I By Versant Development Fund III, LLC The weighted average purchase price for the transaction reported was $9.51250, and the range of prices were between $9.18 and $9.77. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares purchased at each separate price will be provided. Reflects shares, previously held directly by the Reporting Person, which were transferred to the Michael D. Clayman 2006 Revocable Trust. Shares held by Versant Development Fund III, LLC. The Reporting Person is a manager and minority member of Versant Development Fund III, LLC. The Reporting Person disclaims any beneficial ownership of the shares held by Versant Development Fund III, LLC except to the extent of his pecuniary interest in these shares. /s/ Jonathan H. Mahlowitz, Attorney-in-Fact 2016-05-17