Accrued Expenses and Other Current Liabilities - Schedule of Accrued Expenses and Other Current Liabilities (Detail) - USD ($) $ in Thousands	Mar. 31, 2016	Dec. 31, 2015
Payables and Accruals [Abstract]
Clinical research	$ 444	$ 552
Contract manufacturing services	2,778	1,444
Payroll and other employee-related expenses	797	1,649
Regulatory Services	65	64
Consultant fees and expenses	99	70
Professional services fees	293	434
Interest expense	81	81
Other	235	73
Total accrued expenses and other current liabilities	$ 4,792	$ 4,367