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Stock-Based Compensation (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2019
Jun. 30, 2018
Jun. 30, 2019
Jun. 30, 2018
Stock-Based Compensation        
Stock options and other incentive awards granted (in shares) 150,404 178,586 155,080 183,736
Allocated share-based compensation expense $ 2,205 $ 2,345 $ 4,833 $ 5,110
Stock-Based Compensation        
Unrecognized stock-based compensation cost, net of estimated forfeiture 12,000   12,000  
Research and development        
Stock-Based Compensation        
Allocated share-based compensation expense 81 150 242 341
Selling, general and administrative expenses        
Stock-Based Compensation        
Allocated share-based compensation expense $ 2,124 $ 2,195 $ 4,591 $ 4,769