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Stock-Based Compensation (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Apr. 24, 2017
Apr. 01, 2017
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Stock-Based Compensation            
Allocated share-based compensation expense     $ 2,661 $ 3,262 $ 7,771 $ 8,706
Stock-Based Compensation            
Unrecognized stock-based compensation cost, net of estimated forfeiture     16,300   16,300  
Research and development expenses            
Stock-Based Compensation            
Allocated share-based compensation expense     162 297 503 774
Selling, general and administrative expenses            
Stock-Based Compensation            
Allocated share-based compensation expense     $ 2,499 $ 2,965 $ 7,268 $ 7,932
Employee And Non Employee Stock Option [Member]            
Stock-Based Compensation            
Stock options and other incentive awards granted (in shares)     27,590 62,600 211,326 1,263,350
Employee Stock Option [Member]            
Stock-Based Compensation            
Stock options and other incentive awards granted (in shares)   1,100,000        
Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested Options Forfeited, Number of Shares 600,000