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Stock-Based Compensation (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Apr. 24, 2017
Apr. 01, 2017
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Stock-Based Compensation            
Allocated share-based compensation expense     $ 2,345 $ 2,951 $ 5,110 $ 5,444
Stock-Based Compensation            
Unrecognized stock-based compensation cost, net of estimated forfeiture     18,200   18,200  
Research and development expenses            
Stock-Based Compensation            
Allocated share-based compensation expense     150 246 341 477
Selling, general and administrative expenses            
Stock-Based Compensation            
Allocated share-based compensation expense     $ 2,195 $ 2,705 $ 4,769 $ 4,967
Stock Options            
Stock-Based Compensation            
Stock options and other incentive awards granted (in shares)     178,586 1,197,500 183,736 1,200,750
Employee Stock Option [Member]            
Stock-Based Compensation            
Stock options and other incentive awards granted (in shares)   1,100,000        
Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested Options Forfeited, Number of Shares 600,000