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Stock-Based Compensation - Stock-Based Compensation (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Stock-Based Compensation      
Total stock-based compensation $ 15,234 $ 21,839 $ 14,683
Stock-Based Compensation      
Unrecognized compensation expense $ 27,100    
Future forfeiture rate (as a percent) 2.00%    
Period for recognition of compensation cost 2 years    
Research and development expenses      
Stock-Based Compensation      
Total stock-based compensation $ 3,003 4,570 2,403
Selling, general and administrative expenses      
Stock-Based Compensation      
Total stock-based compensation $ 12,231 $ 17,269 $ 12,280