Stock-Based Compensation (Details) (USD $)	3 Months Ended
Mar. 31, 2014	Mar. 31, 2013
Stock-Based Compensation
Allocated share-based compensation expense	$ 3,557,000	$ 4,984,000
Research and development expenses
Stock-Based Compensation
Allocated share-based compensation expense	592,000	928,000
Selling, general and administrative expenses
Stock-Based Compensation
Allocated share-based compensation expense	2,965,000	4,056,000
Stock options
Stock option activity
Stock options granted (in shares)	190,000	0
Non-Performance Based Stock Awards
Stock-Based Compensation
Unrecognized stock-based compensation cost, net of estimated forfeiture	$ 33,200,000

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

-Section 50

-Paragraph 1

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Reference 2: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

-Section S99

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-Subparagraph (SAB TOPIC 14.F)

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Reference 3: http://www.xbrl.org/2003/role/presentationRef

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Reference 4: http://www.xbrl.org/2003/role/presentationRef

-Publisher SEC

-Name Staff Accounting Bulletin (SAB)

-Number Topic 14

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- Definition

Unrecognized cost of unvested share-based compensation awards.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

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-Name Accounting Standards Codification

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Net number of share options (or share units) granted during the period.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef

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