Stock-Based Compensation (Details) (USD $)	3 Months Ended		9 Months Ended
	Sep. 30, 2013	Sep. 30, 2012	Sep. 30, 2013	Sep. 30, 2012
Stock-Based Compensation
Allocated share-based compensation expense	$ 3,936,000	$ 3,748,000	$ 13,988,000	$ 14,361,000
Research and development expenses
Stock-Based Compensation
Allocated share-based compensation expense	798,000	697,000	2,647,000	2,564,000
Selling, general and administrative expenses
Stock-Based Compensation
Allocated share-based compensation expense	3,138,000	3,051,000	11,341,000	11,797,000
Stock options
Stock option activity
Stock options granted (in shares)	450,000	55,000	1,200,000	356,000
Non-Performance Based Stock Awards
Stock-Based Compensation
Unrecognized stock-based compensation cost, net of estimated forfeiture	$ 37,700,000		$ 37,700,000