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Stock-Based Compensation (Details) (USD $)	3 Months Ended		6 Months Ended
Stock-Based Compensation (Details) (USD $)	Jun. 30, 2013	Jun. 30, 2012	Jun. 30, 2013	Jun. 30, 2012
Stock-Based Compensation
Allocated share-based compensation expense	$ 5,068,000	$ 3,696,000	$ 10,052,000	$ 10,614,000
Research and development expenses
Stock-Based Compensation
Allocated share-based compensation expense	921,000	509,000	1,849,000	1,570,000
Selling, general and administrative expenses
Stock-Based Compensation
Allocated share-based compensation expense	4,147,000	3,187,000	8,203,000	9,044,000
Stock options
Stock option activity
Stock options granted (in shares)	725,000	286,000	725,000	301,000
Restricted stock units
Restricted stock unit activity
Restricted stock units granted (in shares)	0	0	0	0
Non-Performance Based Stock Awards
Stock-Based Compensation
Unrecognized stock-based compensation cost, net of estimated forfeiture	$ 35,000,000		$ 35,000,000

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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