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Stock-Based Compensation (Details) (USD $)	3 Months Ended
Stock-Based Compensation (Details) (USD $)	Mar. 31, 2013	Mar. 31, 2012
Stock-Based Compensation
Allocated share-based compensation expense	$ 4,984,000	$ 6,918,000
Research and development expenses
Stock-Based Compensation
Allocated share-based compensation expense	928,000	1,061,000
Selling, general and administrative expenses
Stock-Based Compensation
Allocated share-based compensation expense	4,056,000	5,857,000
Non-Performance Based Stock Awards
Stock-Based Compensation
Unrecognized stock-based compensation cost, net of estimated forfeiture	$ 28,000,000

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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