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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 QOKoIk2nucax3n/E5gRiccWalwLscGmP0gbDUPzu6h0DgAaskuEjBBAphyNYueAr
 Xd4CfLK38m+hc03k/JPTHw==

<SEC-DOCUMENT>0001490577-10-000001.txt : 20100428
<SEC-HEADER>0001490577-10-000001.hdr.sgml : 20100428
<ACCEPTANCE-DATETIME>20100428160656
ACCESSION NUMBER:		0001490577-10-000001
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20100329
FILED AS OF DATE:		20100428
DATE AS OF CHANGE:		20100428

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Slotin Frank A.
		CENTRAL INDEX KEY:			0001490577

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-53015
		FILM NUMBER:		10777027

	MAIL ADDRESS:	
		STREET 1:		340 EISENHOWER DRIVE
		STREET 2:		STE. 610
		CITY:			SAVANNAH
		STATE:			GA
		ZIP:			31406

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PURESPECTRUM, INC.
		CENTRAL INDEX KEY:			0001415306
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-EMPLOYMENT AGENCIES [7361]
		IRS NUMBER:				000000000
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		542 EAST 3RD STREET
		CITY:			BROOKLYN
		STATE:			NY
		ZIP:			11218
		BUSINESS PHONE:		646 383 2404

	MAIL ADDRESS:	
		STREET 1:		542 EAST 3RD STREET
		CITY:			BROOKLYN
		STATE:			NY
		ZIP:			11218

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	INTERNATIONAL MEDICAL STAFFING
		DATE OF NAME CHANGE:	20071016
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>primary_doc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2010-03-29</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001415306</issuerCik>
        <issuerName>PURESPECTRUM, INC.</issuerName>
        <issuerTradingSymbol>PSRU</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001490577</rptOwnerCik>
            <rptOwnerName>Slotin Frank A.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>340 EISENHOWER DRIVE</rptOwnerStreet1>
            <rptOwnerStreet2>STE. 610</rptOwnerStreet2>
            <rptOwnerCity>SAVANNAH</rptOwnerCity>
            <rptOwnerState>GA</rptOwnerState>
            <rptOwnerZipCode>31406</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock $0.0001 Par Value</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>325400</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock $0.0001 Par Value</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>124300</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Children</value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>PureSpectrum Stock Options</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.045</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2010-04-22</value>
            </exerciseDate>
            <expirationDate>
                <value>2014-05-01</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>PSRU Common Stock Options</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>487805</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <ownerSignature>
        <signatureName>Frank A. Slotin</signatureName>
        <signatureDate>2010-04-28</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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