X0306 4 2016-02-11 0 0001590750 SIGNAL GENETICS, INC. SGNL 0001414839 Riccitelli Samuel D C/O SIGNAL GENETICS, INC. 5740 FLEET STREET CARLSBAD CA 92008 1 1 0 0 President & CEO Common Stock 2016-02-11 4 M 0 124252 0.00 A 469382 D Common Stock 2016-02-11 4 F 0 54268 0.46 D 415114 D Restricted Stock Units 0.00 2016-02-11 4 M 0 124252 0.00 D Common Stock 124252 124251 D Each restricted stock unit represents the contingent right to receive the economic equivalent of one share of the Issuer's common stock, payable in shares of common stock, cash or some combination of both, as determined by the Issuer. The restricted stock units reported herein converted into common stock on a one-for-one basis. Shares withheld to satisfy tax withholding obligations. On June 17, 2014, the reporting person was granted 745,511 restricted stock units. Under the terms of the restricted stock unit agreement, 83-1/3% of the award has previously vested. The final 16-2/3% of the award will vest on the two-year anniverary of the grant date. /s/Samuel D. Riccitelli 2016-02-12