X0306 4 2018-05-03 0 0001412486 Cocrystal Pharma, Inc. COCP 0000898860 FROST PHILLIP MD ET AL 4400 BISCAYNE BLVD. MIAMI FL 33137 1 0 1 0 0001380896 Frost Gamma Investments Trust 4400 BISCAYNE BLVD. MIAMI FL 33137 0 0 0 1 Trustee Common Stock 2018-05-03 4 A 0 105263 1.90 A 3655265 I By Frost Gamma Investments Trust These securities were purchased in the Issuer's public offering. The amount of securities beneficially owned has been adjusted for the one for 30 reverse stock split effective January 24, 2018. These securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. Dr. Frost disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that Dr. Frost is the beneficial owner of these securities for purposes of Section 16 or for any other purpose. This Form 4 does not include any of the securities owned directly by OPKO Health, Inc., a company of which Dr. Frost is the Chairman of the Board and Chief Executive Officer, concerning the securities of which Dr. Frost does not hold voting and investment control. Dr. Frost disclaims beneficial ownership of the securities held by OPKO Health, Inc. except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that Dr. Frost is the beneficial owner of the securities for purposes of Section 16 or for any other purpose. /s/ Phillip Frost, M.D., Individually and as Trustee 2018-05-07