<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0707</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001412428</cik>
        <entityName>Centrose LLC</entityName>
        <issuerAddress>
            <street1>918 Deming Way</street1>
            <street2>Suite 100</street2>
            <city>Madison</city>
            <stateOrCountry>WI</stateOrCountry>
            <stateOrCountryDescription>WISCONSIN</stateOrCountryDescription>
            <zipCode>53711</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>608-836-0207</issuerPhoneNumber>
        <jurisdictionOfInc>WISCONSIN</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Limited Liability Company</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <lastName>Prudent</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>918 Deming Way</street1>
                <street2>Suite 100</street2>
                <city>Madison</city>
                <stateOrCountry>WI</stateOrCountry>
                <stateOrCountryDescription>WISCONSIN</stateOrCountryDescription>
                <zipCode>53717</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jon</firstName>
                <middleName>S.</middleName>
                <lastName>Thorson</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2228 Guilford Lane</street1>
                <city>Lexington</city>
                <stateOrCountry>KY</stateOrCountry>
                <stateOrCountryDescription>KENTUCKY</stateOrCountryDescription>
                <zipCode>40513</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
                <relationship>Promoter</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Hayden</firstName>
                <lastName>Leason</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2323 SW 26th Avenue</street1>
                <city>Fort Lauderdale</city>
                <stateOrCountry>FL</stateOrCountry>
                <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                <zipCode>33312</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Raymond</firstName>
                <lastName>Schinazi</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>1860 Montreal Road</street1>
                <city>Tucker</city>
                <stateOrCountry>GA</stateOrCountry>
                <stateOrCountryDescription>GEORGIA</stateOrCountryDescription>
                <zipCode>300084</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001412428-15-000001</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2015-01-30</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>Convertible Note.</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>50000</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>21000000</totalOfferingAmount>
            <totalAmountSold>1450000</totalAmountSold>
            <totalRemaining>19550000</totalRemaining>
            <clarificationOfResponse>$1,100,000 of amount sold to date is in the form of a convertible note that may be repaid by the Issuer prior to conversion using amounts raised in the current offering. This is a best efforts offering with no minimum amount that must be sold.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>3</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
                <isEstimate>true</isEstimate>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
                <isEstimate>true</isEstimate>
            </findersFees>
            <clarificationOfResponse>No finders' fees or sales commissions are anticipated, but the issuer has reserved the right to to use the services of a broker, finder, financial consultant, placement agent, venture capital firm or others to assist in the offering.</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>1522000</dollarAmount>
                <isEstimate>true</isEstimate>
            </grossProceedsUsed>
            <clarificationOfResponse>Estimated CEO Salary through 2019.  Does not include any equity compensation that may be offered.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Centrose LLC</issuerName>
                <signatureName>Jame Prudent</signatureName>
                <nameOfSigner>James Prudent</nameOfSigner>
                <signatureTitle>CEO</signatureTitle>
                <signatureDate>2016-01-21</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
