X0306 4 2021-12-14 0 0001806952 Lyell Immunopharma, Inc. LYEL 0001411874 FRIEDMAN CATHY C/O LYELL IMMUNOPHARMA, INC. 201 HASKINS WAY SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Common Stock 2021-12-14 4 J 0 3765842 0.00 D 0 I Lyell Investors, LLC Common Stock 2021-12-14 4 J 0 218722 0.00 A 236370 I MSL FBO J DUANE & C FRIEDMAN TTEE DUANE FAMILY TRUST Common Stock 100000 I The Duane Irrevocable Trust 2020 Pro-rata distribution by Lyell Investors, LLC to its members. Received in a pro-rata distribution from Lyell Investors, LLC. The Reporting Person is a trustee of MSL FBO J DUANE & C FRIEDMAN TTEE DUANE FAMILY TRUST ("Duane Family Trust") and therefore may be deemed to share the power to direct the disposition and vote of the shares held by the Duane Family Trust. The Reporting Person disclaims beneficial ownership of all shares held by Duane Family Trust except to any pecuniary interest therein. The Reporting Person is a trustee of The Duane Irrevocable Trust 2020 ("Duane Irrevocable Trust") and therefore may be deemed to share the power to direct the disposition and vote of the shares held by the Duane Irrevocable Trust. The Reporting Person disclaims beneficial ownership of all shares held by Duane Irrevocable Trust except to any pecuniary interest therein. /s/ Heather Turner, as Attorney-in-Fact 2021-12-14