Income Taxes - Schedule of Significant Components of Deferred Tax Assets (Liabilities) (Details) - USD ($) $ in Thousands	Dec. 31, 2016	Dec. 31, 2015
Deferred tax assets (liabilities)
Deferred revenue	$ 125,634	$ 142,675
License and technology payments	10,532	13,150
Share-based compensation	16,494	11,427
Accrued expenses	530	743
Depreciation	(651)	(617)
Federal and state net operating loss carryforwards	75,177	26,065
Excess tax benefits related to share-based compensation	0	1,630
Research and development credits	3,720	0
Other	2,155	5
Deferred income tax assets	233,591	195,078
Valuation allowance	(233,591)	(171,965)
Net deferred tax assets	$ 0	$ 23,113