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Stock Option and Compensation Plans - Stock Compensation Expense (Details) - USD ($)
$ / shares in Units, shares in Thousands, $ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2016
Sep. 30, 2015
Sep. 30, 2016
Sep. 30, 2015
Stock Option and Compensation Plans        
Share-based compensation expense $ 8,248 $ 7,041 $ 24,889 $ 18,474
ESPP        
Stock Option and Compensation Plans        
Expected weighted average period to recognize share-based compensation costs     6 months  
Unrecognized compensation costs, net of estimated forfeitures 300   $ 300  
Stock options | Employees        
Stock Option and Compensation Plans        
Share-based compensation expense 5,600 3,400 17,300 11,400
Unrecognized share-based compensation costs for option awards, net of estimated forfeitures 48,300   $ 48,300  
Expected weighted average period to recognize share-based compensation costs     2 years 8 months 7 days  
Non-employee Options | Consultants        
Stock Option and Compensation Plans        
Share-based compensation expense 600 1,800 $ 1,500 3,400
Unrecognized share-based compensation costs for option awards, net of estimated forfeitures $ 1,400   $ 1,400  
Expected weighted average period to recognize share-based compensation costs     1 year 5 months 8 days  
Restricted stock units        
Stock Option and Compensation Plans        
RSUs expected to vest (in shares) 513   513  
Weighted-average fair value of RSUs expected to vest (in dollars per share) $ 54.45   $ 54.45  
Aggregate intrinsic value of RSUs expected to vest $ 23,700   $ 23,700  
Restricted stock units | Employees        
Stock Option and Compensation Plans        
Share-based compensation expense 2,000 $ 1,800 $ 6,100 $ 3,700
Expected weighted average period to recognize share-based compensation costs     2 years 6 months 4 days  
Unrecognized compensation costs, net of estimated forfeitures $ 31,700   $ 31,700