Summary of Significant Accounting Policies (Tables)

9 Months Ended

Sep. 30, 2016

Accounting Policies [Abstract]

Summary of the components of collaboration revenue

Below is a summary of the components of the Company’s collaboration revenue for the three and nine months ended September 30, 2016 and 2015:

	Three months ended September 30,				Nine months ended September 30,
	2016		2015		2016		2015
License revenue	$	—	$	—	$	22,937	$	38,083
Research and development activity revenue	1,664		1,594		8,089		6,768
API transfer revenue	—		1,851		14,545		1,851
Joint operating committee revenue	4		3		16		21
Total collaboration revenue	$	1,668	$	3,448	$	45,587	$	46,723

Schedule of share-based compensation expense

Share-based compensation expense includes expenses related to stock options and RSUs granted to employees, non-employee directors and consultants, as well as the option granted to employees to purchase shares under the ESPP, all of which have been reported in the Company’s Statements of Operations as follows:

	Three months ended September 30,				Nine months ended September 30,
	2016		2015		2016		2015
Research and development	$	5,664	$	5,116	$	16,732	$	12,535
General and administrative	2,584		1,925		8,157		5,939
Total	$	8,248	$	7,041	$	24,889	$	18,474