Condensed Unaudited Consolidated Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Operating Activities
Net loss	$ (72,229)	$ (34,536)
Adjustments to reconcile net loss to net cash used in operating activities
Depreciation and other expense	70	21
Amortization and accretion of term loan related costs	419	0
Amortization of premium and discounts on investment securities	(1,289)	300
Share-based compensation	11,899	5,386
Changes in operating assets and liabilities:
Prepaid expense and other assets	6,238	435
Accrued interest receivable	96	(66)
Accrued research and development expenses	9,019	(1,486)
Accounts payable and accrued expenses	(4,817)	(7,562)
Change in working capital	1	(4)
Net cash used in operating activities	(50,593)	(37,512)
Investing Activities
Purchase of marketable securities	0	(48,897)
Purchase of property and equipment	(233)	(116)
Maturities of marketable securities	39,505	14,865
Net cash provided by (used in) investing activities	39,272	(34,148)
Financing Activities
Proceeds from employee stock plan purchases	2,589	2,080
Net cash provided by financing activities	2,589	2,080
Net decrease in cash and cash equivalents	(8,732)	(69,580)
Cash and cash equivalents
Beginning of period	476,304	261,447
End of period	467,572	191,867
Supplemental disclosure of cash paid
Interest expense paid in cash	$ 2,406	$ 0