Consolidated Statements of Changes in Stockholders' Equity - USD ($) shares in Thousands, $ in Thousands	Total	Underwritten Offering	Junior Series A Preferred Stock	Common Stock	Common Stock Underwritten Offering	Additional paid-in capital	Additional paid-in capital Underwritten Offering	Accumulated Deficit	Accumulated Other Comprehensive Income (Loss)
Balance at beginning of period (in shares) at Dec. 31, 2019			0	49,627
Balance at beginning of period at Dec. 31, 2019	$ 117,203		$ 0	$ 50		$ 597,679		$ (480,526)	$ 0
Increase (Decrease) in Stockholders' Equity
Issuance of common stock and pre-funded warrants, net (in shares)				28,504
Issuance of common stock and pre-funded warrants, net	116,883			$ 28		116,855
Issuance of common stock in connection with license acquisition (in shares)				8,649
Issuance of common stock in connection with private offering	33,237			$ 9		33,228
Issuance of common stock under employee stock compensation plan (in shares)				841
Issuance of common stock under employee stock compensation plans	461			$ 1		460
Share-based compensation	8,323					8,323
Issuance of common stock under the exercise of pre-funded warrants (in shares)				2,500
Issuance of common stock under the exercise of pre-funded warrants	0			$ 2		(2)
Net loss	(84,547)							(84,547)
Unrealized gain on available for sale securities, net of tax	3								3
Balance at end of period (in shares) at Dec. 31, 2020			0	90,121
Balance at beginning of period at Dec. 31, 2020	191,563		$ 0	$ 90		756,543		(565,073)	3
Increase (Decrease) in Stockholders' Equity
Issuance of common stock and pre-funded warrants, net (in shares)					23,748
Issuance of common stock and pre-funded warrants, net		$ 270,319			$ 24		$ 270,295
Issuance of common stock under employee stock compensation plan (in shares)				1,408
Issuance of common stock under employee stock compensation plans	2,016			$ 1		2,015
Share-based compensation	11,245					11,245
Net loss	(114,522)							(114,522)
Unrealized gain on available for sale securities, net of tax	(93)								(93)
Balance at end of period (in shares) at Dec. 31, 2021			0	115,277
Balance at beginning of period at Dec. 31, 2021	360,528		$ 0	$ 115		1,040,098		(679,595)	(90)
Increase (Decrease) in Stockholders' Equity
Issuance of common stock and pre-funded warrants, net (in shares)					15,353
Issuance of common stock and pre-funded warrants, net		$ 324,290			$ 15		$ 324,275
Issuance of common stock under employee stock compensation plan (in shares)				6,010
Issuance of common stock under employee stock compensation plans	8,513			$ 7		8,506
Share-based compensation	26,676					26,676
Net loss	(185,211)							(185,211)
Unrealized gain on available for sale securities, net of tax	(139)								(139)
Balance at end of period (in shares) at Dec. 31, 2022			0	136,640
Balance at beginning of period at Dec. 31, 2022	$ 534,657		$ 0	$ 137		$ 1,399,555		$ (864,806)	$ (229)