Licensing and Commercialization Agreements - License Agreement with University of Massachusetts for the miniCEP290 Program (Details)		1 Months Ended		12 Months Ended
	Jun. 30, 2022 EUR (€)	Sep. 30, 2019 USD ($)	Jul. 31, 2019 USD ($) shares	Dec. 31, 2022 USD ($) shares	Dec. 31, 2022 EUR (€) shares
University Of Massachusetts (UMass) | miniCEP290 | License Agreements
Agreement
Shares issued for license fees (in shares) | shares			75,000
Licensing agreement term			10 years
University Of Massachusetts (UMass) | miniCEP290 | License Agreements | Research and development
Agreement
Payments for license fees		$ 400,000
University Of Massachusetts (UMass) | miniCEP290 | License Agreements | Research and development | Achievement of Specified Clinical and Regulatory Milestones
Agreement
Shares issued for license fees (in shares) | shares			75,000	75,000	75,000
Payments for license fees			$ 14,750,000	$ 14,750,000
University Of Massachusetts (UMass) | miniCEP290 | License Agreements | Research and development | Specified Commercial Sales Milestones Related to a Licensed Product
Agreement
Payments for license fees			$ 48,000,000	$ 48,000,000
University Of Massachusetts (UMass) | miniCEP290 | License Agreements | General and administrative
Agreement
Payments for license fees		$ 18,000
DelSiTech | License Agreements
Agreement
Termination notice period	60 days
DelSiTech | Avacincaptad Pegol | License Agreements
Agreement
Payments for license fees | €	€ 1,250,000
DelSiTech | Avacincaptad Pegol | Achievement Of Specified Commercial Sales Milestones | License Agreements
Agreement
Payments for license fees | €	60,000,000				€ 60,000,000
DelSiTech | Avacincaptad Pegol | Achievement Of Specified Clinical And Development Milestones | License Agreements
Agreement
Amount to be paid on achievement of milestone | €	€ 35,000,000