Summary of Significant Accounting Policies - Schedule of Share-based Compensation Expense (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Share-Based Compensation
Share-based compensation expense	$ 26,676	$ 11,245	$ 8,323
Research and development
Share-Based Compensation
Share-based compensation expense	11,865	6,522	4,166
General and administrative
Share-Based Compensation
Share-based compensation expense	$ 14,811	$ 4,723	$ 4,157