Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2022

Accounting Policies [Abstract]

Schedule of Weighted-average Assumptions Used to Estimate Grant Date Fair Value of Stock Options

The weighted-average assumptions used to estimate grant date fair value of stock options using the Black-Scholes option pricing model were as follows for the years ended December 31, 2022, 2021 and 2020:

	Years ended December 31,
	2022	2021	2020
Expected common stock price volatility	84%	114%	118%
Risk-free interest rate	1.38%-4.29%	0.31%-1.22%	0.22%-1.34%
Expected term of options (years)	4.6	5.2	4.6
Expected dividend yield	—	—	—

Schedule of Share-based Compensation Expense

Share-based compensation expense includes expenses related to stock options and RSUs granted to employees, non-employee directors and consultants, as well as the option granted to employees to purchase shares under the ESPP, all of which have been reported in the Company’s Statements of Operations as follows:

	Years ended December 31,
	2022		2021		2020
Research and development	$	11,865	$	6,522	$	4,166
General and administrative	14,811		4,723		4,157
Total	$	26,676	$	11,245	$	8,323