Condensed Unaudited Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Operating Activities
Net loss	$ (126,150)	$ (81,489)
Adjustments to reconcile net loss to net cash used in operating activities
Depreciation and other expense	80	24
Amortization and accretion of term loan related costs	172	0
Amortization of premium and discounts on investment securities	450	918
Share-based compensation	18,330	6,997
Changes in operating assets and liabilities:
Income tax receivable	0	1,765
Prepaid expense and other assets	(3,204)	726
Accrued interest receivable	82	449
Accrued research and development expenses	(3,020)	(916)
Accounts payable and accrued expenses	(1,660)	(4,662)
Accrued interest payable	405	0
Change in working capital	(22)	63
Net cash used in operating activities	(114,537)	(76,125)
Investing Activities
Purchase of marketable securities	(165,469)	(56,245)
Purchase of property and equipment	(440)	0
Maturities of marketable securities	117,499	136,447
Net cash (used in) provided by investing activities	(48,410)	80,202
Financing Activities
Proceeds from employee stock plan purchases	7,123	1,672
Proceeds from term loan	50,000	0
Payment of term loan issuance costs	(2,523)	0
Proceeds from follow-on public offering, net	0	107,757
Net cash provided by financing activities	54,600	109,429
Net increase (decrease) in cash and cash equivalents	(108,347)	113,506
Cash and cash equivalents
Beginning of period	261,447	66,373
End of period	153,100	179,879
Supplemental disclosure of cash paid
Income tax refunds received	0	1,765
Supplemental disclosures of non-cash information related to investing and financing activities
Operating right-of-use assets obtained in exchange for lease obligations	953	2,086
“Interest expense” paid in cash	$ 486	$ 0