Business (Details)	1 Months Ended
	Sep. 30, 2022 patient product_candidate	Oct. 31, 2019 patient
Adeno-Associated Virus Mediated Gene Therapy Program
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Number of product candidates in preclinical development | product_candidate	2
Avacincaptad Pegol
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Reduction in mean rate of growth	14.30%	27.70%
Reduction in mean rate of growth without using square root transformation	17.70%	35.40%
Patients in trial | patient	448	286