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Common Stock - Narrative (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 12 Months Ended
Dec. 06, 2019
Jul. 22, 2019
Jun. 30, 2020
Jul. 31, 2019
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Class of Stock [Line Items]              
Number of warrants issued (in shares)     1,914,280        
Payments of stock issuance costs $ 3,000   $ 10,100        
Proceeds from issuance of common stock and pre-funded warrants, net, and related to acquisition     $ 150,100        
Payment of other stock issuance costs 400            
Sale of stock, consideration received on transaction $ 42,600            
License Agreements | University Of Massachusetts (UMass) | miniCEP290              
Class of Stock [Line Items]              
Shares issued for license fees (in shares)   75,000   75,000      
Shares issued for license agreement (in shares)   100,000          
Underwritten Offering              
Class of Stock [Line Items]              
Sale of stock, number of shares issued in transaction (in shares)     28,503,220        
Sale of stock, price per share (in dollars per share)     $ 4.10        
Underwritten Offering, Underwriters              
Class of Stock [Line Items]              
Sale of stock, price per share (in dollars per share)     $ 3.854        
Private Placement              
Class of Stock [Line Items]              
Sale of stock, number of shares issued in transaction (in shares)     8,649,453        
Warrant price (USD per share)     $ 4.099        
Proceeds from issuance of common stock and pre-funded warrants, net, and related to acquisition         $ 33,237 $ 0 $ 0
Private Placement, Underwriters              
Class of Stock [Line Items]              
Warrant price (USD per share)     $ 3.853        
Public Stock Offering              
Class of Stock [Line Items]              
Sale of stock, number of shares issued in transaction (in shares) 6,250,000            
Sale of stock, price per share (in dollars per share) $ 4.00            
Number of warrants issued (in shares) 3,750,000            
Warrant price (USD per share) $ 3.999            
Proceeds from issuance of common stock and pre-funded warrants, net, and related to acquisition         $ 116,883 $ 42,565 $ 0
Over-Allotment Option              
Class of Stock [Line Items]              
Sale of stock, number of shares issued in transaction (in shares) 1,500,000            
Sale of stock, price per share (in dollars per share) $ 3.736            
Warrant price (USD per share) $ 3.735