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Commitments and Contingencies - Narrative (Details)
shares in Millions, $ in Millions
1 Months Ended
Mar. 12, 2019
USD ($)
Oct. 30, 2018
USD ($)
shares
May 31, 2019
USD ($)
licensed_product
Jun. 30, 2018
USD ($)
Sep. 30, 2011
USD ($)
Commitments and contingencies          
Number of licensed products | licensed_product     1    
Fees and costs paid to plaintiff's counsel $ 0.3        
License Agreements | Archemix | C5 Licensed Product | Achievement of specified clinical and regulatory milestones | Maximum          
Commitments and contingencies          
Amount to be paid on achievement of milestone         $ 57.5
License Agreements | Archemix | C5 Licensed Product | First indication | Maximum          
Commitments and contingencies          
Amount to be paid on achievement of milestone         30.5
License Agreements | Archemix | C5 Licensed Product | Second and third indication | Maximum          
Commitments and contingencies          
Amount to be paid on achievement of milestone         24.5
License Agreements | Archemix | C5 Licensed Product | Sustained delivery applications | Maximum          
Commitments and contingencies          
Amount to be paid on achievement of milestone         2.5
License Agreements | Archemix | C5 Licensed Product | Achievement of specified commercial milestones | Maximum          
Commitments and contingencies          
Amount to be paid on achievement of milestone         $ 22.5
RHO-adRP License Agreement | University of Florida Research Foundation (UFRF) | Specified clinical, marketing approval and reimbursement approval milestones with respect to a licensed product          
Commitments and contingencies          
Amount to be paid on achievement of milestone       $ 23.5  
RHO-adRP License Agreement | University of Florida Research Foundation (UFRF) | Specified commercial sales milestones with respect to a licensed product          
Commitments and contingencies          
Amount to be paid on achievement of milestone       $ 70.0  
Inception 4          
Commitments and contingencies          
Contingent consideration arrangements, maximum amount   $ 105.0      
Contingent consideration arrangements, maximum amount | shares   7.2      
Contingent consideration arrangements, contingently issuable shares as a percentage of shares outstanding   19.90%      
Inception 4 | GA Product          
Commitments and contingencies          
Clinical and marketing approval milestones   $ 45.0      
Inception 4 | Wet AMD Product          
Commitments and contingencies          
Clinical and marketing approval milestones   $ 60.0      
Research and development | BEST1 License Agreement | University Of Florida Research Foundation (UFRF) And University Of Pennsylvania (Penn) | Primary Licensed Product | Specified clinical, marketing approval and reimbursement approval milestones with respect to a licensed product          
Commitments and contingencies          
Payments for license fees     $ 15.7    
Research and development | BEST1 License Agreement | University Of Florida Research Foundation (UFRF) And University Of Pennsylvania (Penn) | Primary Licensed Product | Specified commercial sales milestones with respect to a licensed product          
Commitments and contingencies          
Payments for license fees     48.0    
Research and development | BEST1 License Agreement | University Of Florida Research Foundation (UFRF) And University Of Pennsylvania (Penn) | Other Licensed Product | Specified clinical, marketing approval and reimbursement approval milestones with respect to a licensed product          
Commitments and contingencies          
Payments for license fees     3.1    
Research and development | BEST1 License Agreement | University Of Florida Research Foundation (UFRF) And University Of Pennsylvania (Penn) | Other Licensed Product | Specified commercial sales milestones with respect to a licensed product          
Commitments and contingencies          
Payments for license fees     $ 9.6