XML 69 R52.htm IDEA: XBRL DOCUMENT v3.10.0.1
Commitments and Contingencies (Details) - USD ($)
shares in Millions, $ in Millions
1 Months Ended
Oct. 30, 2018
Oct. 31, 2018
Dec. 31, 2018
Commitments and contingencies      
Loss contingency estimate, plaintiff's counsel fees     $ 0.3
License Agreements | Archemix | C5 Licensed Product | Achievement of specified clinical and regulatory milestones | Maximum      
Commitments and contingencies      
Amount to be paid on achievement of milestone     57.5
License Agreements | Archemix | C5 Licensed Product | First indication | Maximum      
Commitments and contingencies      
Amount to be paid on achievement of milestone     30.5
License Agreements | Archemix | C5 Licensed Product | Second and third indication | Maximum      
Commitments and contingencies      
Amount to be paid on achievement of milestone     24.5
License Agreements | Archemix | C5 Licensed Product | Sustained delivery applications | Maximum      
Commitments and contingencies      
Amount to be paid on achievement of milestone     2.5
License Agreements | Archemix | C5 Licensed Product | Achievement of specified commercial milestones | Maximum      
Commitments and contingencies      
Amount to be paid on achievement of milestone     22.5
RHO-adRP License Agreement | University of Florida Research Foundation (UFRF) | Specified Clinical, Marketing Approval and Reimbursement Approval Milestones Related to a Licensed Product      
Commitments and contingencies      
Amount to be paid on achievement of milestone     23.5
RHO-adRP License Agreement | University of Florida Research Foundation (UFRF) | Specified Commercial Sales Milestones Related to a Licensed Product      
Commitments and contingencies      
Amount to be paid on achievement of milestone     $ 70.0
Inception 4      
Commitments and contingencies      
Contingent consideration $ 105.0 $ 105.0  
Contingently issuable shares, asset acquisition (in shares) 7.2 7.2  
Contingently issuable shares, asset acquisition, as a percentage of total shares outstanding 19.90% 19.90%  
Inception 4 | GA      
Commitments and contingencies      
Clinical and marketing approval milestones $ 45.0    
Inception 4 | Wet AMD      
Commitments and contingencies      
Clinical and marketing approval milestones $ 60.0