Selected Quarterly Financial Information (unaudited) (Tables)

12 Months Ended

Dec. 31, 2018

Quarterly Financial Information Disclosure [Abstract]

Summary of the quarterly results of operations

The following is a summary of the quarterly results of operations for the years ended December 31, 2018 and 2017:

	2018
	March 31			June 30			September 30			December 31
Collaboration revenue	$	—		$	—		$	—		$	—
Research and development expenses	7,686			8,516			9,407			16,128
General and administrative expenses	5,645			6,332			5,968			5,667
Loss from operations	(13,331		)	(14,848		)	(15,375		)	(21,795		)
Net income (loss) attributable to common stockholders	$	(13,073	)	$	(13,209	)	$	(14,745	)	$	104,114
Basic earnings (loss) per common share	$	(0.36	)	$	(0.37	)	$	(0.41	)	$	2.62
Diluted earnings (loss) per common share	$	(0.36	)	$	(0.37	)	$	(0.41	)	$	2.62

	2017
	March 31			June 30			September 30		December 31
Collaboration revenue	$	1,662		$	1,661		$	206,654	$	—
Research and development expenses	31,979			15,657			10,707		7,946
General and administrative expenses	13,159			8,552			7,059		6,913
Income (loss) from operations	(43,476		)	(22,548		)	188,888		(14,859		)
Net income (loss) attributable to common stockholders	$	(43,122	)	$	(22,204	)	$	189,073	$	(9,542	)
Basic earnings (loss) per common share	$	(1.20	)	$	(0.62	)	$	5.26	$	(0.26	)
Diluted earnings (loss) per common share	$	(1.20	)	$	(0.62	)	$	5.25	$	(0.26	)