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Restructuring Activities (Details) - USD ($)
$ in Thousands
6 Months Ended
Jan. 26, 2017
Jun. 30, 2018
Dec. 31, 2017
Jan. 31, 2017
Accrued Severance and Other Employee Costs        
Restructuring Cost and Reserve [Line Items]        
Percent of personnel expected to be effected by reduction in workforce       80.00%
Accrual balance for severance and benefit costs   $ 447 $ 2,529  
Early termination payment   $ 0    
One Penn Plaza LLC | Lease Termination        
Restructuring Cost and Reserve [Line Items]        
Early termination payment $ 900      
Otsuka America Pharmaceutical, Inc. | Lease Termination        
Restructuring Cost and Reserve [Line Items]        
Early termination payment $ 1,200