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Licensing and Commercialization Agreements - Narrative (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended 22 Months Ended
Jun. 30, 2018
Aug. 31, 2017
Jul. 31, 2017
Jun. 30, 2016
Mar. 31, 2015
Sep. 30, 2014
May 31, 2014
Jun. 30, 2018
Sep. 30, 2017
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2016
Research and Development Arrangement, Contract to Perform for Others [Line Items]                          
Upfront fees received   $ 16,900                      
Total collaboration revenue               $ 0 $ 206,700 $ 1,661 $ 0 $ 3,323  
Novartis Pharma AG | Licensing and Commercialization Agreement                          
Research and Development Arrangement, Contract to Perform for Others [Line Items]                          
Upfront fees received     $ 189,800       $ 200,000            
Achievement of specified patient enrollment milestones | Novartis Pharma AG | Licensing and Commercialization Agreement                          
Research and Development Arrangement, Contract to Perform for Others [Line Items]                          
Patient enrollment-based milestone revenue achieved       $ 30,000 $ 50,000 $ 50,000             $ 130,000
Research and development | University of Florida Research Foundation (UFRF) | RHO-adRP License Agreement                          
Research and Development Arrangement, Contract to Perform for Others [Line Items]                          
License fees paid $ 500                        
Research and development | Specified clinical, marketing approval and reimbursement approval milestones with respect to a licensed product | University of Florida Research Foundation (UFRF) | RHO-adRP License Agreement                          
Research and Development Arrangement, Contract to Perform for Others [Line Items]                          
License fees paid 23,500                        
Research and development | Specified commercial sales milestones with respect to a licensed product | University of Florida Research Foundation (UFRF) | RHO-adRP License Agreement                          
Research and Development Arrangement, Contract to Perform for Others [Line Items]                          
License fees paid 70,000                        
General and administrative | University of Florida Research Foundation (UFRF) | RHO-adRP License Agreement                          
Research and Development Arrangement, Contract to Perform for Others [Line Items]                          
License fees paid $ 30