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Stock Option and Compensation Plans - Stock Compensation Expense (Details) - USD ($)
3 Months Ended 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Stock Option and Compensation Plans        
Share-based compensation expense $ 4,988,000 $ 8,309,000 $ 11,052,000 $ 16,641,000
Stock options | Employees        
Stock Option and Compensation Plans        
Share-based compensation expense 3,600,000 5,500,000 8,000,000 11,600,000
Unrecognized share-based compensation costs for option awards, net of estimated forfeitures 19,600,000   $ 19,600,000  
Expected weighted average period to recognize share-based compensation costs     2 years 3 months 18 days  
Non-employee Options | Consultants        
Stock Option and Compensation Plans        
Share-based compensation expense 100,000 500,000 $ 200,000 900,000
Unrecognized share-based compensation costs for option awards, net of estimated forfeitures $ 300,000   $ 300,000  
Expected weighted average period to recognize share-based compensation costs     2 years 1 month 13 days  
Restricted stock units        
Stock Option and Compensation Plans        
RSUs expected to vest (in shares) 365,000   365,000  
Weighted average fair value of RSUs expected to vest (in dollars per share) $ 31.83   $ 31.83  
Aggregate intrinsic value of RSUs expected to vest $ 900,000   $ 900,000  
Number of shares granted (in shares)     248,000  
Restricted stock units | Employees        
Stock Option and Compensation Plans        
Share-based compensation expense 1,300,000 $ 2,300,000 $ 2,600,000 $ 4,100,000
Expected weighted average period to recognize share-based compensation costs     2 years 4 months 28 days  
Unrecognized compensation costs, net of estimated forfeitures 8,900,000   $ 8,900,000  
Restricted stock units | Consultants        
Stock Option and Compensation Plans        
Expected weighted average period to recognize share-based compensation costs     2 years 2 months 18 days  
Unrecognized compensation costs, net of estimated forfeitures $ 100,000   $ 100,000  
Number of shares granted (in shares)   0   0
ESPP        
Stock Option and Compensation Plans        
Share-based compensation expense   $ 0 $ 100,000 $ 0
Expected weighted average period to recognize share-based compensation costs     3 months  
Shares of common stock issued under plan (in shares)     4,746 0
Number of shares available for future purchases under the plan (in shares) 995,254   995,254