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Summary of Significant Accounting Policies (Details 3) (USD $)
In Thousands, unless otherwise specified
 3 Months Ended
Mar. 31, 2015
Mar. 31, 2014
Summary of Significant Accounting Policies    
Dividend yield (as a percent) 0.00%us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate  
Share-Based Compensation    
Share-based compensation expense $ 5,054us-gaap_AllocatedShareBasedCompensationExpense $ 2,729us-gaap_AllocatedShareBasedCompensationExpense
Research and development    
Share-Based Compensation    
Share-based compensation expense 3,115us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_ResearchAndDevelopmentExpenseMember		 1,662us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_ResearchAndDevelopmentExpenseMember
General and administrative    
Share-Based Compensation    
Share-based compensation expense $ 1,939us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_GeneralAndAdministrativeExpenseMember		 $ 1,067us-gaap_AllocatedShareBasedCompensationExpense
/ us-gaap_IncomeStatementLocationAxis
= us-gaap_GeneralAndAdministrativeExpenseMember