Licensing and Commercialization Agreement with Novartis Pharma AG (Details) - USD ($) $ in Thousands		1 Months Ended					3 Months Ended						7 Months Ended	12 Months Ended
	May. 19, 2014	Apr. 30, 2015	Mar. 31, 2015	Oct. 31, 2014	Sep. 30, 2014	May. 31, 2014	Dec. 31, 2015	Sep. 30, 2015	Jun. 30, 2015	Mar. 31, 2015	Dec. 31, 2014	Sep. 30, 2014	Mar. 31, 2015	Dec. 31, 2015	Dec. 31, 2014
Agreement
Total collaboration revenue							$ 4,782	$ 3,448	$ 1,597	$ 41,678	$ 1,684	$ 39,575		$ 51,505	$ 41,259
License revenue
Agreement
Total collaboration revenue														38,083	38,373
Research and development activity revenue
Agreement
Total collaboration revenue														8,378	2,000
API transfer revenue
Agreement
Total collaboration revenue														5,020	883
Joint operating committee revenue
Agreement
Total collaboration revenue														24	$ 3
Novartis Pharma AG
Agreement
Upfront fees received						$ 200,000
Patient enrollment-based milestone revenue achieved			$ 50,000		$ 50,000								$ 100,000
Licensing and Commercialization Agreement | Novartis Pharma AG
Agreement
Upfront fees received	$ 200,000
Licensing and Commercialization Agreement | Novartis Pharma AG | Achievement of specified patient enrollment milestones
Agreement
Milestone payment received		$ 50,000		$ 50,000
Patient enrollment-based milestone revenue achieved			$ 50,000		$ 50,000								$ 100,000
Recognized revenues														51,500
Licensing and Commercialization Agreement | Novartis Pharma AG | Achievement of specified patient enrollment milestones | Maximum
Agreement
Aggregate amount receivable on achievement of milestone							130,000							130,000
Licensing and Commercialization Agreement | Novartis Pharma AG | Achievement of specified regulatory approval milestones | Maximum
Agreement
Aggregate amount receivable on achievement of milestone							300,000							300,000
Licensing and Commercialization Agreement | Novartis Pharma AG | Achievement of specified commercial sale milestone | Maximum
Agreement
Aggregate amount receivable on achievement of milestone							$ 400,000							$ 400,000